Laboratory of Adaptive Immunity

We uncover fundamental aspects of T-cell biology in infection, cancer and autoimmunity

+ Immunity, + T cells, + signalling, + disease models

Ondřej Štěpánek

Group leader

ondrej.stepanek@img.cas.cz

laboratory website

Scientific Career – Milestones

since 2016: Research Group Leader, IMG, Prague

2012-2016: Postdoctoral Fellow, University Hospital Basel, Switzerland

2011: PhD, Faculty of Science, Charles University, Prague

Origin and function of antigen-inexperienced memory-like T cells

We have discovered that antigen-inexperienced memory-like T cells are formed from relatively highly self-reactive T cells under various hygienic conditions, including germ-free and wild mice. Our results suggest that this process is a mechanism of self-tolerance. [pubmed] [doi]

Investigation of T-cell diversity using single cell transcriptomics

We have established a pipeline for the analysis of T-cell diversity using single cell transcriptomics that cosiderably accelerates research in our laboratory.

Correlation between immune symptoms and Bardet-Biedl syndrome

We have discovered a link between ciliopathy in Bardet-Biedl syndrome and defects in the immune system. We continue to focus on the link between cilia and immunity. [pubmed] [doi]