Laboratory of Leukocyte Signalling

We seek to understand how proteins of leukocyte signalling pathways regulate the immune response and prevent disease

+ leukocyte signal transduction, + inflammation, + immune response, + autoinflammatory diseases, + membrane adaptor proteins

Tomáš Brdička

Group leader

Tomáš Brdička

Scientific Career – Milestones

since 2013: Research Group Leader, IMG, Prague
2003-2006: Postdoctoral Fellow, University of California San Francisco, USA
2003: PhD, Faculty of Science, Charles University, Prague
1996-2003: PhD práce, IMG, Prague; Heidelberg University, Germany; University Magdeburg, Germany

Bone damage by deregulated NADPH oxidase in a model of autoinflammatory disease

By studying autoinflammatory diseases that are characterized by spontaneous sterile inflammation of various tissues, we have found deregulated production of reactive oxygen species by neutrophil NADPH oxidase. Our findings suggest that this is a critical mechanism of inflammatory bone damage in the mouse model of autoinflammatory diseases. [pubmed] [doi]

Regulation of CXCR4 signalling and hematopoiesis by WBP1L adaptor protein

We have discovered a so far uncharacterized membrane adaptor WBP1L that negatively regulates signalling through the chemokine receptor CXCR4. This receptor has a key role in haematopoiesis and cancer metastases. We have also described the function of the WBP1L adaptor in hematopoietic progenitors and leukemic cells. [pubmed] [doi]

Threshold setting for immunoreceptor signalling by Src-family kinases

We have discovered a new layer of regulation in antigen receptor signal transduction that determines the threshold for downstream pathway activation by Src-family kinases. These are key signal transducers of antigen receptor signalling in B and T cells. [pubmed] [doi]

Research Reports

2020-2022 / 2017-2019 / 2015-2016 / 2013-2014