Development of therapeutic exosomes and gene therapy for Diamond Blackfan Anemia (DBA)
Starting date: March 1, 2023
Duration: 36 Months
EU research and innovation programme: Horizon Europe / Marie Skłodowska-Curie Actions (GRANT AGREEMENT NUMBER: 101072427)
The position is available in the Laboratory of Transgenic Models of Diseases, which closely cooperates with the Czech Centre for Phenogenomics (CCP; www.phenogenomics.cz), which is providing comprehensive expertise in in vivo research of gene functions using animal models, especially the full spectrum of genetic engineering, including generation of mouse models of diseases, advanced phenotyping and imaging techniques, and correction of a gene function to propose disease treatment.
Laboratory of Transgenic Models of Diseases and Czech Centre for Phenogenomics, Institute of Molecular Genetics, BIOCEV campus, Prumyslova 595, 252 50 Vestec, Czech Republic
Supervisor: PD. Dr. rer. nat. habil. Radislav Sedláček
We are looking for a highly motivated and enthusiastic candidate with the following qualifications:
More than 300 million people worldwide are suffering from more than 6000 rare diseases that are mostly caused by a single inherited mutation. Repair of the defective gene by gene editing is the only possible curative therapy. However, only for very few rare diseases such gene editing therapy has reached the clinic. The “Gene therapy of Rare Diseases” (GetRadi) consortium aims to contribute strongly to the establishment of more gene therapies for rare diseases by training the future leaders in gene therapy of rare diseases preforming ambitious projects with the following objectives:
Strong participation of the pharmaceutical industry to research projects and training, development of novel in vitro and in vivo models for rare diseases to test gene therapies in relevant settings, and application of several unique genome editing tools to treat rare diseases are the hallmarks of the GetRadi network.
Applicants need to fully comply with these eligibility criteria:
The job application in English consisting of a cover letter and structured CV should be sent to Mr. Marketa Morska (firstname.lastname@example.org) by 31 October 2022. If you have any questions related to the positions, please send them to this email as well.
We thank all who apply for their interest; however, only those candidates who are considered for an interview will be contacted.
The candidate is expected to enrol in a doctoral program from March 1, 2023.
The position is offered under the conditions of the Marie Skłodowska Curie Action Doctoral Network Scheme and therefore offers a salary that is determined by the regulations of this scheme. This equates the gross monthly salary 2,422 EUR (including Marie Skłodowska Curie mobility allowance) / 2,908 EUR (including family allowance, if applicable).
In addition to their individual scientific projects, all ESR will benefit from further continuing education, which includes scientific skills courses, transferable skills courses, as well as active participation in workshops and conferences and secondments to partner labs. The European GetRadi training network wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation.