Institute of Molecular Genetics of the Czech Academy of Sciences
+ stem cells, + signalling pathways, + gastrointestinal tract, + cancer, + haematological disorders
Using modern molecular biology methods, we identified the gene/protein TROY as a novel stem cell marker and determined its potential function in intestinal epithelial cells. [pubmed] [doi]
The results of this study show that some mutations in the JAK2 gene enhance JAK2 signalling and cause a specific clinical course of the disease. This “mutational landscape” is known in the genome of patients with myeloproliferative neoplasms. [pubmed] [doi]
We have shown that the (sub)population of mesenchymal cells forms a specialized microenvironment, the so-called niche, for epithelial cells in the colon. These mesenchymal cells secrete Wnt factors – when secretion is blocked, stem cell renewal is disrupted, leading to compromised integrity of the colon epithelium. [pubmed] [doi]
