Institute of Molecular Genetics of the Czech Academy of Sciences
The main aim of the two-week course is to inform the participants about the recent progress in the fields of molecular biology, genetics and biomedicine together with selected new biotechnology approaches.
Typical attendees are the first and second year PhD students from biomedical programs, but other participants are also very welcome. The course is accredited (MPGS0034) at the Charles University.
All lectures will be held in English by active scientists.
The course is composed of 43 lectures organized into the following thematic blocks:
DNA/cell nucleus: nuclear microstructure-function relationship, nuclear lamina, spatio-temporal organization, human genome structure and evolution, CRISPR.
RNA: organization and regulation of RNA polymerase II transcription, RNA and innate immunity, non-coding RNAs, RNA & cellular structures.
Proteins: eukaryotic protein synthesis, proteomics and proteomes, structural biology tools, prions, synthetic protein biology.
Cell biology and signaling: integrative biology of intermediate microfilaments, biophysics of ciliary transport, actomyosin in early embryo morphogenesis, interaction between cells and the extracellular matrix, microtubules and signal transduction.
Developmental biology: evo-devo of animal development, early mouse development, zebrafish as a model system in developmental biology, zebrafish as a model system in developmental biology, transposable elements in mammalian development.
Biomedicine – genomics: rare genetic variants in Mendelian complex diseases, sequencing methods, RNA delivery particles, CRISPR and synthetic biology, genetic engineering.
Biomedicine – cancer biology: horizontal mitochondrial transfer in cancer, roles of tumor suppressor p53, metabolic communication in tumors, DNA repair and human pathologies, chromosomal aberrations in cancer cells.
Biomedicine – hematology & immunology: CAR-T biology & therapy, metabolic rewiring in leukemia therapy resistance, tumor immunology and cancer immunotherapy, oxygen transport at the molecular level, non-coding RNAs in leukemias and lymphomas.
Workshops: academic ecosystem, career in science, research ethics and scientific misconduct, conflict management.
At the end of the course participants receive the credit.
For more information and online registration, please visit – https://pokroky.img.cas.cz/.
Deadline: 23 October 2025