31. 10. 2022
Already in 1903, the Russian biologist Nikolai Konstantinovich Koltsov (1872-1940) introduced the concept of the cytoskeleton, a “cellular skeleton” that is responsible for cellular shapes. But only now is it becoming clear how important for tissue integrity are the cytoskeletal crosslinker proteins aka cytolinkers. Mutations in the genes encoding these proteins frequently lead to the development of diseases associated with tissue fragility. Well-known examples are plectinopathies, multisystem disorders manifesting with skin blistering and muscular dystrophy.
3. 5. 2022
In the journal Science, an international team of scientists with Czech participation described a yet unknown process by which cancer cells try to resist the effects of radiotherapy, i.e. radiation. They found that one of the cells’ defence strategies is that they cause further DNA damage to themselves and pause their cycle before starting to divide. This gives them time to repair the more serious damage caused by radiotherapy.
22. 3. 2022
“Everything is improving, Czech science has moved on considerably in the last thirty years – we have opened up to the world, we have state-of-the-art equipment, new institutes. I am very happy for that,” says biochemist and geneticist Václav Pačes in an interview for UK Forum. Although he has spent most of his professional life at the Czech Academy of Sciences, he has been in close contact with Charles University since childhood.
25. 2. 2022
“Our previous studies in transgenic mouse models have shown that plectin mutations affect the ability of cells to form functional cell junctions in, for example, the epithelia of the intestinal mucosa or liver bile ducts,” says Martin Gregor.
Exposition Fascinating Genome …or how to light up a fish
Laboratory for Children CEITEC at Masaryk University, Petr Svoboda is the original co-author of the project and a member of the Board of Directors of Bioskop. IMG owns the registered trademark Bioskop and the domain bioskop.cz.