This easy-to-use system combines active tissue clearing and immunolabeling into one high-throughput device, allowing you to switch between clearing and labeling modes simply by changing buffers. SmartBatch+ is compatible with different tissue types and large intact samples.
An advance on the CLARITY tissue clearing method, Clear+ provides maximum optical transparency with no tissue expansion or contraction. In immunolabeling mode, eFLASH and patented SE technologies uniformly label whole organs.Unlike other methods like iDISCO and CUBIC, SmartBatch+ actively preserves fluorescent protein signal.
Compared with passive methods, SmartBatch+ enables faster clearing and labeling, resulting in significantly improved penetration of antibodies and dyes into the tissue or organ.To image deep into fixed non-transparent biological samples, it is necessary to apply this tissue clearing protocol.
