Institute of Molecular Genetics of the Czech Academy of Sciences
Are you an academic researcher working in chemical biology, genetics, or early-stage drug discovery? The CZ-OPENSCREEN National Infrastructure for Chemical Biology offers access to advanced technologies, expertise, and services to help turn innovative research ideas into impactful results.
We support researchers from around the world in applying chemical biology approaches to basic research and early-stage drug discovery through dedicated programs and access to our infrastructure.
Our high-throughput screening (HTS) services enable the identification of biologically active compounds using biological assays, state-of-the-art technologies, and robotic platforms. Our resources include a broad portfolio of biochemical and cell-based assays, approximately 100 normal and tumor cell lines, and a chemical library of more than 200,000 compounds.
We also welcome chemists seeking to explore the biological activity and therapeutic potential of newly synthesized compounds.
Our services include:
Whether you aim to identify novel molecular probes, investigate biological mechanisms, or develop and optimize promising compounds, CZ-OPENSCREEN provides tailored support to advance your research.
Have an innovative research idea? Apply to the CZ-OPENSCREEN Open Access call and take your project to the next level.
This call is primarily intended for researchers from academic institutions engaged in independent or basic research, such as universities and research institutes in the Czech Republic and abroad. Other potential users may collaborate with CZ-OPENSCREEN under the conditions specified on our website.
For an initial consultation regarding your research project, please get in touch with us by email at cz-openscreen@img.cas.cz or by using the contact form.
Applicants must complete the Open Access application form and provide detailed information on the project’s scientific and methodological relevance, expected outcomes, and financial requirements.
The project budget must be consulted with a CZ-OPENSCREEN facility member. Approved financial support will be covered directly by CZ-OPENSCREEN. Travel, accommodation, and per diem expenses are not eligible for support. Please note that there is no legal entitlement to receive this funding.
All applications will be evaluated by members of the CZ-OPENSCREEN Open Access Committees based on the proposed project’s scientific focus.
Biological rationale – evaluation of how effectively the project builds on current biological knowledge, identifies relevant gaps in understanding, and presents a clear, coherent biological justification for the proposed research strategy and anticipated outcomes.
Technical feasibility – assessment of the suitability and maturity of the proposed technical approaches, the availability of required expertise and infrastructure, and the likelihood that the project can be successfully executed within the planned budget, timeline, and technical constraints.
Novelty and impact – the extent to which the project introduces original concepts, hypotheses, or approaches beyond the current state of the art, and the potential of the expected results to significantly advance biological knowledge, methodology, or future applications.
Plans for post-screening stages – the extent to which the project presents a clear, logical, and feasible strategy for follow-up studies after the screening phase, including validation, hit prioritization, and progression toward mechanistic or functional characterization.
After project approval, an Open Access contract will be executed. As part of the collaboration, a Material Transfer Agreement will also be established between CZ-OPENSCREEN and the user. High-throughput screening data and other results generated during the research may be embargoed for up to 3 years to publish priority data or protect intellectual property.
Call opening – 15 October 2026
Application deadline – 15 November 2026
Results announcement – 15 December 2026