A hitherto unknown protein could help in anticancer treatment

  • published: 10. 6. 2021

Experts from the Institute of Molecular Genetics of the Czech Academy of Sciences managed to find a hitherto unknown protein and describe its role in cell division. Their knowledge could be used in the future to control cell division in anticancer treatment.

“The general principles of cell division and mitotic spindle organization have been known for many years. Now our team has managed to find a completely new signal path, which has so far escaped attention. Understanding the mechanisms by which the FAM110A protein and CK1 kinase are involved in the control of cell division can contribute to the rational use of inhibitors in anticancer therapy, ”describes Libor Macůrek from the Institute of Molecular Genetics of the Czech Academy of Sciences.

 

Authors: Libor Macůrek, Martin Jakubec

 

 

 

Publication:

Aquino Perez C, Burocziova M, Jenikova G, Macurek L: CK1-mediated phosphorylation of FAM110A promotes its interaction with mitotic spindle and controls chromosomal alignment. EMBO Rep 2021, e51847. [pubmed] [doi]

 

More information:

Libor Macůrek, M.D., Ph.D.,
phone: (+420) 241 063 210, e-mail: libor.macurek@img.cas.cz,
web: www.img.cas.cz/research/libor-macurek

 

Contact for media:

Martin Jakubec, Ph.D.,
phone: (+420) 296 443 159, e-mail: m.jakubec@img.cas.cz

 

Full press release as PDF (in Czech).