Institute of Molecular Genetics of the Czech Academy of Sciences
In the new research, a team of scientists led by David Staněk (IMG) described a protein that ensures correct assembly, and thus the function of the so-called splicing complex, one of the largest molecular complexes in human cells composed of 150 different components.
In the new research, a team of scientists led by David Staněk (IMG) described a protein that ensures correct assembly, and thus the function of the so-called splicing complex, one of the largest molecular complexes in human cells composed of 150 different components. Their results were published a few days ago by Nature Communications journal.
Molecular scissors called spliceosome
Source: RCSB PDB 6AHD
Klimešová K, Vojáčková J, Radivojević N, Vandermoere F, Bertrand E, Verheggen C, Staněk D: TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation. Nat Commun 2021 12(1): 3646. [pubmed] [doi]
Assoc. Prof. David Staněk, Ph.D.,
phone: (+420) 296 443 118, e-mail: david.stanek@img.cas.cz,
web: www.img.cas.cz/research/david-stanek
Martin Jakubec, Ph.D.,
phone: (+420) 296 443 159, e-mail: m.jakubec@img.cas.cz
Full press release as PDF (in Czech).