How to flawlessly assemble molecular scissors with 150 pieces

  • published: 21. 6. 2021

In the new research, a team of scientists led by David Staněk (IMG) described a protein that ensures correct assembly, and thus the function of the so-called splicing complex, one of the largest molecular complexes in human cells composed of 150 different components. Their results were published a few days ago by Nature Communications journal.

Molecular scissors called spliceosome

Molecular scissors called spliceosome

Authors: David Staněk, Martin Jakubec




Klimešová K, Vojáčková J, Radivojević N, Vandermoere F, Bertrand E, Verheggen C, Staněk D: TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation. Nat Commun 2021 12(1): 3646. [pubmed] [doi]


More information:

Assoc. Prof. David Staněk, Ph.D.,
phone: (+420) 296 443 118, e-mail:,


Contact for media:

Martin Jakubec, Ph.D.,
phone: (+420) 296 443 159, e-mail:


Full press release as PDF (in Czech).