How to flawlessly assemble molecular scissors with 150 pieces
In the new research, a team of scientists led by David Staněk (IMG) described a protein that ensures correct assembly, and thus the function of the so-called splicing complex, one of the largest molecular complexes in human cells composed of 150 different components. Their results were published a few days ago by Nature Communications journal.
Molecular scissors called spliceosome
Source: RCSB PDB 6AHD
Klimešová K, Vojáčková J, Radivojević N, Vandermoere F, Bertrand E, Verheggen C, Staněk D: TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation. Nat Commun 2021 12(1): 3646. [pubmed] [doi]
Contact for media:
Martin Jakubec, Ph.D.,
phone: (+420) 296 443 159, e-mail: email@example.com
Full press release as PDF (in Czech).