Institute of Molecular Genetics of the Czech Academy of Sciences
| Grant name | Provider | Duration | Investigator | Web |
|---|---|---|---|---|
| Development of brain organoid models to study the role of cellular senescence in the pathogenesis of glioblastoma | Czech Science Foundation | 2024-2026 | Z. Hodný | Go to website |
| Senescence of neurons in mutated mTOR-related focal cortical dysplasia - from the cell mechanisms to targeted treatment | Ministry of Health | 2024-2027 | Z. Hodný | Go to website |
| Advancing Cancer Treatment: Discovery and Targeting of New Anticancer Compounds | Ministry of Health | 2025-2028 | Z. Hodný |
| Grant name | Provider | Duration | Investigator | Web |
|---|---|---|---|---|
| Protein modifications in DNA damage signalling: Mechanisms and cancer relevance | Czech Science Foundation | 2008-2010 | J. Bartek | Go to website |
| The role of the JAK/STATsignalling pathway in cellular senescence | Czech Science Foundation | 2008-2012 | Z. Hodný | Go to website |
| Systems-level, multi-layer understanding of cellular responses to ionizing radiation | Seventh Framework Programme EU | 2009-2011 | J. Bártek | Go to website |
| Role of RECQ5 DNA helicase in maintenance of genomic stability | Czech Science Foundation | 2009-2013 | P. Janščák | Go to website |
| Mechanisms of DNA damage checkpoint termination | Czech Science Foundation | 2010-2012 | J. Bartek | Go to website |
| Role of Wip1 phosphatase in the DNA damage response | Czech Science Foundation | 2010-2012 | L. Macůrek | Go to website |
| Role of the Rothmund-Thomson syndrome gene product in maintenance of genomic stability | Czech Science Foundation | 2010-2014 | P. Janščák | Go to website |
| Post-translational modifications of Daxx and their functional relevance in DNA damage response and cellular senescence | Czech Science Foundation | 2011-2013 | H. Hanzlíková | Go to website |
| Mechanisms of radioresistance of prostate cancer cells | Czech Science Foundation | 2013-2016 | Z. Hodný | Go to website |
| Premature cellular senescence: Mechanisms and links with cancer | Czech Science Foundation | 2013-2016 | J. Bártek | Go to website |
| The role of 5-azacytidine on immunoepigenetics and genotoxic stress in the treatment of myelodysplastic syndrome. | Ministry of Health | 2013-2015 | J. Bártek | Go to website |
| Role of cellular senescence in carcinogenesis and tumour resistance | Czech Academy of Sciences | 2013-2015 | S. Hubáčková | |
| Identification of protein complexes associated with genotoxic RNA:DNA hybrids and their role in maintenance of genomic stability | Ministry of Education, Youth and Sports | 2014-2016 | J. Dobrovolná | Go to website |
| Molecular mechanism of genomic instability caused by oncogene activation | Czech Science Foundation | 2014-2016 | P. Janščák | Go to website |
| Study of molecular mechanisms suppressing genomic instability associated with transcription and replication stress | Czech Academy of Sciences | 2014-2015 | J. Dobrovolná | |
| Role of oxidative stress in the interplay between cellular senescence and apoptosis | Czech Science Foundation | 2015-2017 | Z. Hodný | Go to website |
| WIP1 phosphatase function in the cell response to DNA damage | Czech Academy of Sciences | 2016-2017 | K. Burdová | |
| Plasmonic nanoparticles for theranostics with tunable optothermal properties | Czech Science Foundation | 2016-2018 | J. Bartek | Go to website |
| Mechanisms of IFNgama-induced cellular senescence and phenotypic plasticity | Czech Science Foundation | 2017-2019 | Z. Hodný | Go to website |
| Ribosomal stress: mechanisms and relevance to cancer | Czech Science Foundation | 2017-2019 | J. Bártek | Go to website |
| Study of molecular mechanisms involved in suppression of transcription-associated genomic instability | Czech Science Foundation | 2017-2019 | P. Janščák | Go to website |
| Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging | Ministry of Education, Youth and Sports | 2017-2020 | P. Hozák | Go to website |
| Inhibition of JAK/STAT3 signalling pathway in cancer therapy | Czech Science Foundation | 2018-2020 | Z. Hodný | Go to website |
| Identification and functional analysis of proteins participating in restart of DNA replication forks after collisions with transcriptional complexes | Czech Academy of Sciences | 2019-2020 | M. Andrš | |
| Ribosomal stress, rDNA stability and cellular senescence: role of PML | Czech Science Foundation | 2019-2021 | J. Bártek | Go to website |
| Exploring mechanisms of DNA replication restart upon collisions between transcription and replication complexes | Czech Science Foundation | 2019-2021 | P. Janščák | Go to website |
| Application of tumor tropism of stem cells for photothermal therapy of glioblastoma with gold nanorods - preclinical study. | Ministry of Health | 2019-2022 | J. Bártek | Go to website |
| RECQ5 helicase function in DNA replication reactivation after collision between transcriptional and replication complexes | Czech Academy of Sciences | 2020-2021 | Z. Hašanová | |
| New approaches to overcome therapeutic resistance of glioblastoma multiforme: Focus on cellular senescence and cerebral organoid model | Czech Science Foundation | 2020-2022 | Z. Hodný | Go to website |
| The therapeutic potential of novel mTOR inhibitors within the process of ageing | Czech Science Foundation | 2020-2022 | Z. Hodný | Go to website |
| Anti-viral treatment strategy repurposing for glioblastoma: Clinical evaluation and biomarker studies | Ministry of Health | 2021-2024 | J. Bártek | Go to website |
| New approaches to overcome therapeutic resistance of glioblastoma multiforme: Focus on cellular senescence and cerebral organoid model | Czech Academy of Sciences | 2021-2022 | J. Novák | |
| Alzheimer´s disease and aging: can mTOR inhibitors kill two birds with one drug? | Czech Science Foundation | 2023-2025 | Z. Hodný | Go to website |
| Exploring the role of PML nucleolar compartment in rDNA maintenance in normal and cancer cells | Czech Science Foundation | 2023-2025 | J. Bártek | Go to website |
