The main aim of the two-week course is to inform the participants about the recent progress in the ﬁelds of molecular biology, genetics and biomedicine together with selected new biotechnology approaches.
Typical attendees are the ﬁrst and second year PhD students from biomedical programs, but other participants are also very welcome. The main aim of the two-week course is to inform the participants about the recent progress in the ﬁelds of molecular biology, genetics and biomedicine together with selected new biotechnology approaches. The course is accredited (MPGS0034) at the Charles University.
All lectures will be held in English by active scientists.
The course is composed of ~ 40 lectures organized into the following thematic blocks:
DNA/cell nucleus: nuclear microstructure-function relationship, organization and function of the 3D genome, human genome structure and evolution.
RNA: pivotal role of RNA polymerase in gene expression, organization and regulation of RNA polymerase II transcription, non-canonical RNA caps, piRNA pathways, regulation of RNA splicing.
Proteins: eukaryotic protein synthesis, ribosome structure and function, structural biology tools, proteomics and proteomes.
Cell biology and signaling: microtubules and signal transduction, membrane microdomains, cellular iron-oxidative stress-DNA damage-ferroptosis, eukaryotic flagella and cilia, genome integrity in healthy cells and cancer, endothelial cells: metabolism and heterogeneity in disease, multifaceted mitochondrial ATP synthases, insect hormonal signaling exploration via molecular genetics and chemical biology, memory of immune system.
Genomics: meiotic recombination and hybrid sterility, strategies for manipulating gene expression, high throughput gene expression analysis, gene editing in antiviral research.
Biomedicine: current concepts in tumor immunology and immunotherapy, prion, prion strains and prion diseases, rare genetic variants in Mendelian complex diseases, genetics of intellectual disability and autism, leukemogenesis: genetics vs epigenetics, comparative biology of aging, ameloblastin in enamel formation and beyond, molecular tricks of human bacterial pathogens, germline genetic changes causing human tumors, DNA strand breaks and neurodegenerative disease, transcriptional regulation during blood formation, biological clock.
Developmental biology: converting cellular-scale chirality to organismal left-right symmetry breaking, development of the head and neck, Notch signaling.
Workshops: Writing in scientific English, research ethics and scientific misconduct, career paths in science-research and alternatives, scientific communication. Life with science.
At the end of the course participants receive the credit and the presentations will be available for download from a password-protected website.
For more information and online registration, please visit – https://pokroky.img.cas.cz/.
Deadline: October 21, 2022