Institute of Molecular Genetics of the Czech Academy of Sciences
+ haematopoiesis, + lymphocytes, + dendritic cells, + fibroblasts, + lymphoid organs
We characterized the asymmetric distribution of CD4+ and CD8+ T cells in lymphoid organs, demonstrating the dependency of this process on Ebi2 expression. In the absence of Ebi2, CD4+ T cells lose their preferential orientation toward the periphery of lymphoid organs, which precludes timely antigen recognition and impairs anti-pathogenic responses. [pubmed] [doi]
We showed that the development of the splenic cDC2 compartment requires two distinct sources of lymphotoxin. Whereas lymphotoxin-expressing LTi cells regulate the splenic cDC niche size during embryonic and early post-natal development, lymphotoxin-expressing LTi and B cells regulate terminal Esam+ cDC2 development throughout life. [pubmed] [doi]
