Laboratory of Genome Dynamics

We investigate how defects in DNA repair and RNA metabolism lead to human disease

+ DNA single-strand breaks, + ADP-ribosylation, + RNA metabolism, + neurological disease

Hana Hanzlíková

Group leader

Hana Hanzlíková

Scientific Career – Milestones

since 2022: Research Group Leader, IMG, Prague
2015-2017: Postdoctoral Fellow, Genome Damage and Stability Centre, University of Sussex, UK
2008-2014: Postdoctoral Fellow, IMG Prague & Danish Cancer Society Research Center, Copenhagen, Denmark
2007: PhD, Vetsuisse Faculty, University of Bern, Switzerland

An alternative pathway for the processing of Okazaki fragments

We have identified the PARP-dependent DNA repair as an alternative pathway for the processing of canonical DNA replication intermediates. Our results have major implications for cancer research. [pubmed] [doi]

A novel molecular defect in ARH3-mutated neurodegenerative disease

We have found that whilst the absence of ARH3 glycohydrolase does not impede DNA repair, instead it leads to the persistence of aberrant ADP-ribose chromatin “scars” at sites of previous PARP-dependent DNA repair events. [pubmed] [doi]

New insights into PNKP-mutated neurological disease

We implicate reduced rates of DNA single-strand break repair, not DNA double-strand break repair, as the source of both neurodevelopmental and neurodegenerative pathology in PNKP-mutated disease. We also point to the extent of this reduction as the determinant of disease severity. [pubmed] [doi]

Research Reports

2020-2022 / 2017-2019

Additional information about group