Laboratory of Developmental Mechanobiology

We unravel how molecular forces drive embryo morphogenesis and how they evolve

+ quantitative live-imaging, + cytoskeletal dynamics, + nematode genetics, + biophysics, + evolutionary development (evo‑devo)

Teije Corneel Middelkoop

Group leader

Teije Corneel Middelkoop

Scientific Career – Milestones

since 2022: Research Group Leader, IMG, Prague
2015-2022: Postdoctoral Fellow, Biotec/TU Dresden & MPI-CBG Dresden, Germany
2014: PhD, Hubrecht Institute, Utrecht, The Netherlands

Formin-dependent active torque generation drives left-right patterning

By combining quantitative experiments with biophysical models, we have shown that the F-actin elongator Formin facilitates molecular-scale torque generation in early C. elegans embryos. In turn, this drives organismal left-right symmetry breaking. [pubmed] [doi]

Lineage-specific chiral actomyosin flows position embryonic cells

We have found that, in a subset of cells in early C. elegans embryos, the actomyosin cortex displays chiral counter-rotations. These chiral counter-rotations reposition cells relative to each other, which is essential for normal development. [pubmed] [doi]

The dorsoventral body axis aligns with embryo geometry

By performing mechanical and genetic perturbations on early C. elegans embryos, we have shown that actomyosin-dependent force generation aligns the dorsoventral axis with embryo geometry.

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