Laboratory of Immunobiology

We investigate the cellular, molecular and signalling processes underpinning immune homeostasis

+ central and peripheral immune tolerance, + TCR signalling, + TLR signalling, + embryonic haematopoiesis

Dominik Filipp

Group leader

dominik.filipp@img.cas.cz

Scientific Career – Milestones

since 2007: Research Group Leader, IMG, Prague

2001-2007: Research Fellow, Sunnybrook Research Institute, Toronto, Canada

1994-1998: Postdoctoral Fellow, University of Toronto, Canada

1992-1993: Postdoctoral Fellow, CIML, Marseille, France

1991: PhD, Institute of Molecular Genetics, Moscow, Soviet Union

Gastrointestinal autoimmunity associated with loss of central tolerance to enteric α-defensins

We have shown that the physiological role of enteric α-defensin production in the thymus is critical for maintenaning central tolerance in the small intestine. [pubmed] [doi]

Toll-like receptor 2 expression on c-kit⁺ cells tracks the emergence of embryonic definitive hematopoietic progenitors

We have found that the precursors of embryonic hematopoietic cells express Toll-like receptors (TLRs). Using TLR2 as a prototypic TLRs, we have mapped spatiotemporal parameters of the emergence of definitive hematopoietic progenitors. [pubmed] [doi]

Toll-like receptor signalling in thymus controls monocyte-derived dendritic cell recruitment and Treg generation

We have provided a mechanistic insight into the regulation of central tolerance via TLR signalling in mTECs. TLRs regulate the chemotactic recruitment of monocyte-derived CD14+ dendritic cells to the thymic medulla, the cellular composition of which predicates the developmental output of Treg cells. [pubmed] [doi]