Laboratory of Cancer Cell Biology

Current Grants

Grant name Provider Duration Investigator Web
Classification of variants of uncertain significance in CHEK2 and phenotypical characterization of tumours in carriers of deleterious variants Ministry of Health 2019-2022 L. Macůrek Go to website
Bioinformatics and functional analyses of susceptibility variants supporting the ngs-based testing of hereditary cancers in the Czech Republic - II Ministry of Health 2020-2023 L. Macůrek Go to website
Role of truncated PPM1D in genome instability and cancer development Czech Science Foundation 2020-2022 L. Macůrek Go to website
Identification and characterization of proteins involved in G-quadruplex and R-loop metabolism and their relationship with DNA replication Czech Science Foundation 2021-2025 J. Dobrovolná Go to website
Molecular mechanisms involved in reactivation of replication forks stalled by co-transcriptional R-loops Czech Science Foundation 2022-2024 P. Janščák
Impact of mutations in CHEK2 and other predisposing genes on development of breast and ovary carcinoma Czech Academy of Sciences 2022-2023 L. Stolařová
Functional classification of the TP53 gene variants with distinct penetrance and its use for better management of cancer prevention in mutation carriers Ministry of Health 2022-2025 L. Macůrek Go to website

 

Past Grants

Grant name Provider Duration Investigator Web
Role of Wip1 phosphatase in the DNA damage response Czech Science Foundation 2010-2012 L. Macůrek Go to website
Structure and function of proteins involved in DNA damage signaling Czech Science Foundation 2012-2015 L. Macůrek Go to website
Dynamics of DNA damage response in cells Czech Science Foundation 2013-2016 L. Macůrek Go to website
Phosphorylation-mediated signalling in DNA damage response and cancer Ministry of Education, Youth and Sports 2014-2017 L. Macůrek Go to website
Role of R2TP complex in DNA damage response and cell proliferation Czech Science Foundation 2014-2016 Z. Líčeníková Hořejší Go to website
Role of PPM1D/Wip1 truncating mutations in cancer predisposition Worldwide Cancer Research 2014-2016 L. Macůrek Go to website
Bioinformatics and functional analyses of susceptibility variants supporting the NGS-based testing of hereditary cancers in the Czech Republic Ministry of Health 2016-2019 L. Macůrek Go to website
Role of deficient checkpoint barrier in cancerogenesis Czech Science Foundation 2016-2018 L. Macůrek Go to website
Analysis of stromal microenvironment, molecular and immunohistochemical aspects of malignant melanoma Ministry of Health 2016-2019 L. Macůrek Go to website
Novel mechanisms regulating the cell cycle progression and checkpoint Czech Science Foundation 2017-2019 L. Macůrek Go to website
Novel role of PPM1D/Wip1 phosphatase in chromatin organization Czech Science Foundation 2019-2021 L. Macůrek Go to website
Investigation of the control of bioenergetic plasticity of tumor by oncogenic switches Czech Science Foundation 2019-2021 M. Elgendy Go to website