The main interest of the laboratory is to study the molecular mechanism of cell fate determination. We use cytokines/growth factors and small molecules as tools to manipulate the fate of hematopoietic cells in model organisms (zebrafish, lamprey, chicken, mouse) and human primary cells to gain insight into the mechanisms underlying their self-renewal, proliferation and differentiation.
Primitive erythrocytes are the first blood cells generated during embryogenesis. They are thought to arise from lateral plate mesoderm, however tracking their emergence remains challenging and their origin is unclear. Thus, we aim to fate-map primitive erythrocytes from mesodermal derivatives in zebrafish using various molecular genetics, developmental biology and imaging techniques.