Laboratory of Tissue Morphogenesis and Cancer

We unravel cellular, molecular and biophysical mechanisms, which regulate organ formation and whose deregulation leads to tumour formation

+ microenvironment, + cell-to-cell communication, + epithelial-stromal interaction, + mechanical forces, + epithelial morphogenesis, + functional heterogeneity, + organoids

Zuzana Sumbalová Koledová

Group leader

Zuzana Sumbalová Koledová

Scientific Career – Milestones

since 2024: Research Group Leader, IMG, Prague
2021-2023: Research Group Leader, Faculty of Medicine, Masaryk University, Brno, Czech Republic
2013-2021: Postdoctoral & Research Fellow, Faculty of Medicine, Masaryk University, Brno, Czech Republic
2011-2013: Postdoctoral Fellow, University of Manchester, UK
2010: PhD, Faculty of Science, Palacký University, Olomouc, Czech Republic

Fibroblast-induced mammary epithelial branching depends on fibroblast contractility

Using an organoid model we have demonstrated that fibroblast contractility and direct contact between fibroblasts and epithelium are crucial for branching of organoids. Our findings enrich the repertoire of mechanisms by which the stromal cells influence epithelial morphogenesis. [doi]

Milk production in vitro

We have developed a method for milk production in cell culture – in mammary gland organoids. This approach allows not only to study processes of lactation and involution in vitro, but also has a strong biotechnology potential for milk production without the need for animal farming. [pubmed] [doi]

Mammary epithelial branching morphogenesis is regulated by stromal activity of EGFR-SPRY1

We have discovered multiple functions of fibroblasts during mammary morphogenesis, including extracellular matrix remodelling and growth factor production for the epithelium. We have uncovered that these functions are regulated by EGFR signalling and its negative modulator SPRY1. [pubmed] [doi]

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