Laboratory of Cell and Developmental Biology

Current Grants

Grant name Provider Duration Investigator Web
Cellular and molecular-genetic characterization of selected hereditary defects of erythropoiesis Ministry of Health 2019-2022 L. Láníková Go to website
Mechanisms of initiation of early gut tumour stages and regeneration of gut epithelium Czech Academy of Sciences 2020-2022 M. Šťastná
Characterization of early stages of intestinal tumorigenesis induced by non-physiological activation of Wnt signaling Czech Science Foundation 2020-2022 V. Kořínek Go to website
Germline, weakly activating JAK2 variants predisposing to myeloid malignancies: cooperation with driver leukemogenic oncogene Ministry of Health 2021-2024 L. Láníková
Transformations of the gastrointestinal stem cell niche during the development and regeneration Czech Science Foundation 2021-2023 T. Valenta Go to website
Involvement of Wnt/β-catenin signaling in neurogenesis and gliogenesis following brain ischemic injury - analysis at the single cell level Czech Science Foundation 2021-2023 V. Kořínek Go to website
National Cancer Institute Ministry of Education, Youth and Sports 2022-2025 V. Kořínek

 

Past Grants

Grant name Provider Duration Investigator Web
High throughput analysis of chromatin structure for development of novel diagnostic and therapeutic approaches in cancer. Ministry of Education, Youth and Sports 2006-2011 V. Kořínek Go to website
Tumor suppressors in the Wnt signaling pathway Czech Science Foundation 2007-2010 V. Kořínek Go to website
Bacteria in etiology, prevention ant therapy of experimentally induced intestinal inflammation and colon cancer Czech Science Foundation 2011-2014 V. Kořínek Go to website
Wnt signaling in self-renewal and tumorigenesis of the intestinal epithelia Czech Science Foundation 2011-2014 V. Kořínek Go to website
Molecular mechanisms of the tumor suppressor function of the HIC1 gene Czech Science Foundation 2012-2015 V. Kořínek Go to website
Founding the Centre of Transgenic Technologies Ministry of Education, Youth and Sports 2012-2015 R. Sedláček, V. Kořínek, Z. Kozmík Go to website
Development of new chemical compounds with anti-tumor activities or use in regenerative medicine Ministry of Industry and Trade 2012-2015 P. Bartůněk, V. Kořínek Go to website
Molecular mechanisms underlying cell-fate decisions in the intestine Czech Science Foundation 2014-2016 V. Kořínek Go to website
Biomodels for Health – Center for Model Organisms Ministry of Education, Youth and Sports 2015-2019 P. Bartůněk, J. Hejnar, O. Horvath, V. Kořínek, Z. Kozmik, D. Staněk, P. Svoboda Go to website
Molecular pathophysiology of erythroid disorders Ministry of Education, Youth and Sports 2015-2017 L. Láníková Go to website
Molecular bases of clonal heterogeneity and progression of polycythemia vera Czech Science Foundation 2015-2017 L. Láníková Go to website
The Wnt signaling network – novel components and regulatory mechanisms Czech Science Foundation 2015-2017 V. Kořínek Go to website
Diet and microbiota as modulators of gut inflammation and colon cancer Czech Science Foundation 2016-2018 V. Kořínek Go to website
Genetické predispozice k myeloproliferativním onemocnění v JAK/STAT dráze Ministry of Education, Youth and Sports 2017-2021 L. Láníková Go to website
Initiation and progression of myeloproliferative disorders - the role of pathological JAK2 activation in the specific context of EPOR Czech Science Foundation 2017-2019 L. Láníková Go to website
Principal signaling pathways regulating NG2 glia proliferation and defferentiation following brain injuries Czech Science Foundation 2017-2019 V. Kořínek Go to website
The canonical Wnt pathway components involved in non-canonical signaling mechanisms Czech Science Foundation 2018-2020 V. Kořínek Go to website
Wnt ligands and Wnt-secreting cells for intestinal homeostasis, regeneration and colon cancer: a complex world beyond the cancer-activating mutation Czech Science Foundation 2018-2020 T. Valenta Go to website
Role of LGR5-positive stem cells in odontogenesis Czech Science Foundation 2019-2021 V. Kořínek Go to website