Grant Projects

Operational Programme Johannes Amos Comenius

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Call number:02_22_008
Project No:CZ.02.01.01/00/22_008/0004575
Provider:Ministry of Education, Youth and Sports
Total eligible costs:499,640,882.63 CZK
Project implementation:1. 1. 2024 – 31. 10. 2028

RNA for therapy

The goal of the project is to build a research and innovation ecosystem in the field of RNA medicine in the Czech Republic and to expand the therapeutic potential of RNA, which in recent years has become a remarkable therapeutic tool for personalized medicine and immunotherapy, as well as a solution to genetic, infectious and chronic diseases related to RNA metabolism. The project connects top research of key molecular mechanisms in the portfolio of RNA biology and the transformation of the acquired knowledge into practical application.

Call number:02_22_010
Project No:CZ.02.01.01/00/22_010/0007164
Provider:Ministry of Education, Youth and Sports
Total eligible costs:6,517,080.00 CZK
Project implementation:31. 12. 2023 – 31. 03. 2027

System wide Omics analysis of retinoic acid signaling in vertebrate development

The main objective of the project is to develop the internationalisation of the research environment in the Czech Republic through close cooperation and the creation of new projects with the Stowers Institute for Medical Research in Kansas City, Missouri, USA. This will contribute to the improvement of the quality of the Institute of Molecular Genetics of the CAS, especially through publications. The aim of the research project is to understand the mechanisms that control the effect of vitamin A and retinoic acid on embryonic development and in the pathogenesis of disease.

Call number:02_23_015
Project No:CZ.02.01.01/00/23_015/0008189
Provider:Ministry of Education, Youth and Sports
Total eligible costs:178,499,235.00 CZK
Project implementation:1. 1. 2024 – 31. 12. 2026

Upgrade of the large research infrastructure CCP III

The aim of the project is to modernise the large research infrastructure the Czech Centre for Phenogenomics in order to maintain its competitiveness and expand its portfolio of services.

The modernisation will be carried out through the following key activities:

  • KA 1. Project management
  • KA 2. Modernisation or upgrade of large research infrastructure
  • KA 3. Building adjustments necessary for the installation of new instruments
Call number:02_23_015
Project No:CZ.02.01.01/00/23_015/0008203
Provider:Ministry of Education, Youth and Sports
Total eligible costs:188,255,500.00 CZK
Project implementation:1. 1. 2024 – 31. 12. 2026

Modernization of the National Infrastructure for Chemical Biology 2024

The main mission of the National infrastructure of chemical biology (CZ-OPENSCREEN) is the screening of biological activities of compounds and the identification of tools, probes and methods to be used in the basic research of cellular processes, mechanisms of disease genesis and pathophysiological cellular pathway intervention.

The main objective of the project is to modernise the CZ-OPENSCREEN infrastructure through the following key activities KA1 Project management, KA2 Modernisation of IMG laboratories, KA3 Modernisation of UPOL laboratories, KA4 Modernisation of MU laboratories, KA5 Modernisation of UCT laboratories and KA6 Building reconstruction at IMG.

The investment in new laboratories and key equipment will clearly contribute to a further increase in the international quality of research and its results within the infrastructure, while increasing competitiveness not only at the level of Czech science, but also of the Czech Republic itself.

Operational Programme Prague for Competitivenes

European Regional Development Fund
Praque & EU: Investing in your future
www.strukturalni-fondy.cz

Project No:CZ.2.16/3.1.0/21547
Provider:Municipality of Prague

Center for model organisms

The purpose of the project “Center for model organisms” is the purchase of unique equipment and extension of current established technologies to study cellular and molecular interactions within living organisms. The main mission of the project is the establishment of the Center that will carry research in areas of molecular, cell and developmental biology using unique combination of model organisms. As part of the project there will be established a new research platform based on model organism Danio rerio (zebrafish). Research using traditional model organisms will greatly benefit from the implementation of the project mainly thanks to the purchase and implementation of the state-of-the-art microscopy technologies.

Project No:CZ.2.16/3.1.0/24020
Provider:Municipality of Prague

CZ-OPENSCREEN: National Infrastructure for Chemical Biology

The purpose of the project, which started in March 2011, is construction of the infrastructure that will support basic research in the area of chemical biology and genetics and offer Open Access to academic researchers. This infrastructure is being equipped with state-of-the-art technology that includes an integrated robotic system for high-throughput screening, a system for automated microscopic high-content analysis and an integrated robotic system for compound storage and management. The mission of the project is to set up a national infrastructure for chemical biology which includes the national compound collection and the database that enable identification of research tools and probes to be used in basic research and in development of potential therapeutics. CZ-OPENSCREEN is a priority project in The National Roadmap of the Large Infrastructures and will serve as a National node within the ESFRI infrastructure EU-OPENSCREEN (www.eu-openscreen.eu).

Petr Bartůněk is the National Coordinator of CZ-OPENSCREEN.

Project No:CZ.2.16/3.1.0/28026
Provider:Municipality of Prague

Label-free Technology Platform

The project started in September 2012 and should provide equipment for non-invasive real-time monitoring of changes in the living systems with the aim to identify molecules that could be used as tools for further biomedical research or in drug development process. The purchased instruments will supplement the current laboratory equipment within the National infrastructure for chemical biology CZ-OPENSCREEN and IMG.

Petr Bartůněk is the Coordinator of the project.

Operational Programme Research and Development for Innovations

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Project No:CZ.1.05/2.1.00/19.0395
Provider:Ministry of Education, Youth and Sports

Higher quality and capacity of transgenic model breeding

The project will extend the array of tools and instruments in the modern breeding facility BIOCEV/Czech Centre of Phenogenomics (CCP), which has great research and application potential. We wish to enhance production of applicable results and new activities related to the research programme of the Centre, to increase quality of the technology transfer and enhance cooperation with the application sphere. At the same time, we aim to enhance the research capacity of the Centre, which is based on modelling diseases using transgenic mice and rats – without these model organisms, we would not be able to investigate the basic gene functions in the complexity of the entire organism. These tools are represented by modern systems for breeding of laboratory rodents, which must be bred in individually ventilated cages placed in special racks connected to the ventilation and filtration units, protecting the animals against undesired infections. The availability of healthy animals is an absolute prerequisite for proper research, to enable us to produce correct results and cooperate with the application sphere. Beside study of the function of so far unexplored genes, transgenic models are utilized for investigation of novel therapeutic approaches, and our research concepts of the studies of metabolic disorders and aging comply with the national research priorities and European research programmes. Project BIOCEV has already included completion of the CCP building with total cost of ca CZK 270 million and its equipment with instruments and technologies for additional more than CZK 260 million. These are large investments, and their full value and use by the scientific programmes of the Centre will be highly enhanced by increasing the breeding capacities.

Operational Programme Research, Development and Education

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Project No:CZ.02.2.69/0.0/0.0/18_053/0016981
Provider:Ministry of Education, Youth and Sports

International Mobility of IMG Researchers II

The projects of international mobility of researchers, technicians, and administrative staff are focused on strengthening international cooperation and development of human resources. The main objective is to support professional growth of researchers, technicians, and administrative staff and to enhance development of research organizations by reinforcement of their human resources.

Project No:CZ.02.1.01/0.0/0.0/18_046/0016118
Provider:Ministry of Education, Youth and Sports

Modernization of the National Infrastructure for Chemical Biology

The main mission of the National infrastructure of chemical biology (CZ-OPENSCREEN) is the screening of biological activities of compounds and the identification of tools, probes and methods to be used in the basic research of cellular processes, mechanisms of disease genesis and pathophysiological cellular pathway intervention. The project “Modernization of the National Infrastructure for Chemical Biology” aims at modernization of the technological equipment and strengthening of the advancement of basic and applied research and development in the field of chemical biology and genetics within the National Infrastructure for Chemical Biology (CZ-OPENSCREEN). The project’s implementation will clearly contribute to a further increase in the international quality of research and its results within the infrastructure, while increasing competitiveness not only at the level of Czech science, but also of the Czech Republic itself.

Project No:LM2015047 and 16_013/0001777_01
Provider:Ministry of Education, Youth and Sports

ELIXIR-CZ: Czech National Infrastructure for Biological Data

Life science experiments generate an immense and exponentially increasing volume of data. It is necessary to store the data, make it accessible, interoperable and safe. The major aim is to extract key information and analyse the data effectively. The mission of ELIXIR-CZ is to create a sustainable infrastructure for storing, interoperability and sharing of the life science data for further processing and analysis. To complement the listed services ELIXIR-CZ is prepared to provide advanced tools and training to facilitate these activities. ELIXIR-CZ currently provides 9 databases of life science data and 15 tools for their processing and analysis and the number continues growing. Uniqueness of the ELIXIR-CZ lies in expertises provided by specialized groups at significant Czech life research organisations – members of ELIXIR CZ consortium. Jointly they create a bioinformatics platform that offers services for wide research community in the open access regime and is interconnected with services of the e-infrastructures providing technical solutions. The participation of ELIXIR-CZ in the pan European research infrastructure ELIXIR is essential and ELIXIR-CZ benefits from this membership. It increases the visibility of ELIXIR-CZ services and tools, enlarges its user community and it catalyses project based cooperation with other ELIXIR national nodes.

Project No:CZ.02.1.01/0.0/0.0/16_013/0001799
Provider:Ministry of Education, Youth and Sports

Upgrade of the National Infrastructure for Chemical Biology

The project “Upgrade of the National Infrastructure for Chemical Biology” aims at modernization of the technological equipment and strengthening of the advancement of basic and applied research and development in the field of chemical biology and genetics within the National Infrastructure for Chemical Biology (CZ-OPENSCREEN). The project’s scope will consist in modernization of the existing equipment in laboratories associated in the CZ-OPENSCREEN consortium – the host institution IMG and the partner institution Palacky University in Olomouc. The project will ensure acquisition of new instruments – a non-contact acoustic liquid handling device and a compressor station for ensuring the chemical library’s internal environment. Their integration into the existing equipment will help achieve the goals of the project’s scientific programmes and will lead to the improvement and expansion of the infrastructure’s research in general. The research will be implemented by using the existing and modernized research infrastructure and will build on its existing research activities. The project will support activities directed toward the creation of complementary platforms for the testing of the biological activity of small molecules and obtaining data for identifying new molecular probes and tools for further research and validation of compounds suitable for the development of new therapeutics. High-quality project management will guarantee fulfilment of the project’s objectives. The project’s implementation will clearly contribute to a further increase in the international quality of research and its results within the infrastructure, while increasing competitiveness not only at the level of Czech science, but also of the Czech Republic itself.

Project No:CZ.02.1.01/0.0/0.0/16_013/0001789
Provider:Ministry of Education, Youth and Sports

Upgrade of the Czech Centre for Phenogenomics: developing towards translation research

To keep pace with the current development of new technologies and knowledge to decipher complex biological processes linked to genetic base of human disorders, Czech Centre for Phenogenomics (CCP) strives to develop research activities advancing its expertise, service portfolio, and scientific impact. Having established generation of genetically modified models and their standardized phenotyping, CCP aims to advance metabolic and aging analysis as well as data coming from models of rare and other genetic disease. Regarding the systemic approach and data usage, CCP aims to build a bioinformatics group that will analyse data coming from research activities of these grant projects, phenotyping tests of CCP, and later on also serve the user community. A specific link to human medicine, especially to cancer development and its treatment, will be introduced by patient-derived xenographs (PDX) technology, which will include their standardized characterization, maintenance, biobanking, and distribution. Moreover, CCP strives to establish a National PDX reference centre and thus, not only to serve the medical community but also foster biomedical research. The outcome of this effort should be translated into future clinical application, in particular for the personalized medicine approach used in oncology.

Project No:CZ.02.1.01/0.0/0.0/16_013/0001775
Provider:Ministry of Education, Youth and Sports

Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging

Czech-BioImaging, the national infrastructure for biological and medical imaging, is a distributed research infrastructure of leading imaging facilities, which provides open access to a wide portfolio of imaging methods. The availability of these technologies to the scientific community is a a necessary condition for ensuring the competitiveness of biological and medical sciences in the Czech Republic. The aim of this project is modernization of the current instrumentation of the infrastructure and support for own research projects.

Call number:02_16_027
Project No:CZ.02.2.69/0.0/0.0/16_027/0008512
Provider:Ministry of Education, Youth and Sports
Total eligible costs:9,976,178,- CZK
Project implementation:1. 3. 2018 – 30. 11. 2019

International mobility of researchers in priority axis PO 2

The main output of this project lies in professional development of young starting researchers by their stay abroad at significant American and European academic laboratories, along with internationalization of the Institute by enrolling new top scientific capacities from abroad. This international scientific collaboration will allow active development of knowledge and skills, transfer of novel research methods, and starting new international scientific contacts.

This project is co-financed by EU.