Laboratory of Cancer Biology

We elucidate the role of proteasome-dependent protein degradation in intracellular processes involved in cancer development

+ proteasome, + cancer, + protein degradation, + cell cycle, + survival

Lukáš Čermák

Group leader

lukas.cermak@img.cas.cz

Scientific Career – Milestones

since 2018: Research Group Leader, IMG, Prague

2009-2015: Postdoctoral Fellow, Grossman School of Medicine, New York University, USA

2007: PhD, Faculty of Science, Charles University, Prague

Regulation of the Wnt signalling pathway by the ubiquitin-proteasome system (UPS)

We have reviewed the current understanding of how the UPS regulates the Wnt, TGF-β, and Notch signalling pathways and summarized the related findings from mouse models. [pubmed] [doi]

Factors controlling the stability of the antiviral RNA helicase MOV10

We have found that DCAF12, a CUL4-dependent substrate receptor, is responsible for controlling the stability of the essential antiviral RNA helicase MOV10, which is involved in retrotransposition inhibition. [pubmed] [doi]

Novel biochemical pathway involved in the control of centromeric chromatin

In our latest research, we have described a novel biochemical pathway involved in the control of centromeric chromatin during spermatogenesis. [pubmed] [doi]