Laboratory of Biology of the Cell Nucleus

We seek to understand the roles of nuclear phosphoinositides and their interactors in the regulation of gene expression

+ nuclear lipids, + phosphatidylinositol phosphates, + nucleoskeleton, + transcription, + subnuclear compartments

Pavel Hozák

Group leader

Pavel Hozák

Scientific Career – Milestones

od 2012: Director of Czech-BioImaging, National Infrastructure for Biological and Medical Imaging
2007: Professor, Second Faculty of Medicine, Charles University, Prague
od 2006: Research Group Leader, IMG, Prague
2001: Doctor of Science, Czech Academy of Sciences
1995-2005: Research Group Leader, Institute of Experimental Medicine, Czech Academy of Sciences, Prague

Elucidating the function of phosphoinositides in gene expression

We have mapped the landscape of nuclear phosphoinositides and their effectors, which has helped us to elucidate the roles of phosphoinositides in transcription regulation. [pubmed] [doi]

Identification of the nuclear role of actin and actin-binding proteins

We have characterized the function of several actin-related proteins in the eukaryotic nucleus and determined their roles in the regulation of gene expression. [pubmed] [doi]

Discovery of nuclear myosin I and its involvement in transcription

We have uncovered the role of nuclear myosin I as a transcription factor for RNA polymerases I and II. [pubmed] [doi]

Research Reports

2017-2019 / 2015-2016 / 2013-2014 / 2011-2012 / 2009-2010 / 2008 / 2007