Laboratory of Biology of the Cytoskeleton


Structure and Function of Cytoskeleton – Faculty of Science, Charles University in Prague

Following topics are included in the lecture-course: organisation and function of cytoskeleton, structure and dynamics of microtubules, microtubule-associated proteins, microtubule motor proteins, microtubules and cell division, structure and dynamics of microfilaments, microfilament-associated proteins, microfilament motor proteins, microfilaments and muscle contraction, structure and dynamics of intermediate filaments, proteins associated with intermediate filaments, membrane skeleton, nuclear skeleton, interactions between cytoskeleton subsystems, cytoskeleton and signal transduction, pathological changes of cytoskeleton, methods for study structure and dynamics of cytoskeletal components. In the course are presented experimental results from Laboratory of Biology of the Cytoskeleton at IMG.

Information on the subject in the SIS UK – MB150P67.

Please note, the lectures are given in czech language only.


1.Cytoskelet úvod
2.Mikrotubuly, stavební proteiny, modifikace, struktura, nukleace, asociované proteiny, dynamická nestabilita mikrotubulů
3.Mikrofilamenta, stavební proteiny, struktura, nukleace, asociované proteiny, dynamika mikrofilament
4.Střední filamenta, stavební proteiny, struktura, asociované proteiny, dynamika středních filament
5.Interakce mezi cytoskeletálními systémy
6.Molekulární motory
7.Cytoskelet a přenos signálů
8.Membránový skelet
9.Jaderný skelet
11.Cytoskelet prokaryot
Cytoskelet a choroby
12.Speciální techniky studia cytoskeletu