Institute of Molecular Genetics of the Czech Academy of Sciences
+ plasma membrane signalosomes, + membrane receptor signalling, + immunoreceptor regulators, + mast cells
We have found that activation of mast cells can be, surprisingly, also mediated by the Thy-1 glycoprotein bound to the plasma membrane via lipidic tail. [pubmed] [doi]
We have discovered that LAT2 and PAG proteins (two TRAP previously discovered at IMG) control signal transduction via the IgE receptor in an unexpected way. Thus, thet affect the activation of mast cells, key players in allergies. [pubmed] [doi]
By searching for interacting partners of the ORMDL3 protein, which is involved in asthma and other inflammatory diseases, we have found that ORMDL3 interacts with 5-lipoxygenase. This finding has opened new insights into the role of ORMDL3 in regulating immune responses. [pubmed] [doi]
