Laboratory of Leukocyte Signalling

We seek to understand the mechanisms that link leukocyte signalling and function to immune-mediated diseases

+ leukocyte signal transduction, + inflammation, + immune response, + inflammatory diseases, + membrane adaptor proteins

Tomáš Brdička

Group leader

tomas.brdicka@img.cas.cz

Scientific Career – Milestones

since 2013: Research Group Leader, IMG, Prague

2003-2006: Postdoctoral Fellow, University of California San Francisco, USA

2003: PhD, Faculty of Science, Charles University, Prague

1996-2003: PhD work, IMG, Prague; Heidelberg University, Germany; University Magdeburg, Germany

Neutrophil-driven inflammation in chronic recurrent multifocal osteomyelitis

We discovered that neutrophils from patients with pediatric autoinflammatory disease chronic recurrent multifocal osteomyelitis show upregulated inflammatory pathways and chronic activation, revealing their contribution to disease pathology.

Bone damage by deregulated NADPH oxidase in a model of autoinflammatory disease

We found that deregulated production of reactive oxygen species by neutrophil NADPH oxidase drives bone damage in the mouse model of autinflammatory osteomyelitis, revealing a critical mechanism of autoinflammatory disease development. [pubmed] [doi]

Regulation of CXCR4 signalling and hematopoiesis by WBP1L adaptor protein

We discovered a novel membrane adaptor WBP1L, which negatively regulates CXCR4 signaling, key to hematopoiesis and metastasis. We also revealed WBP1L’s critical role in hematopoietic progenitors and bone marrow transplantation. [pubmed] [doi]