Institute of Molecular Genetics of the Czech Academy of Sciences
| Grant name | Provider | Duration | Investigator | Web |
|---|---|---|---|---|
| GetRadi - Gene Therapy of Rare Diseases | Horizon Europe | 2022-2026 | R. Sedláček | Go to website |
| SARS-Cov-2: understanding the entry, multi-organ spread and immune response in the context of vaccination and re-infection | Czech Science Foundation | 2022-2025 | R. Sedláček | Go to website |
| Gene engineered killer T cells for the therapy of acute myeloid leukemia | Ministry of Health | 2022-2025 | R. Sedláček | Go to website |
| Mitochondrial function is essential for liver tumour formation and liver regeneration | Ministry of Health | 2022-2025 | J. Procházka | Go to website |
| Towards precision medicine and gene therapy | Czech Academy of Sciences | 2022-2026 | R. Sedláček | Go to website |
| Advanced genome editing: Extracellular vesicle in disease modelling and mouse models development | Ministry of Education, Youth and Sports | 2023-2026 | R. Sedláček | Go to website |
| Systemic omics analysis of retinoic acid signaling pathways in vertebrate development | Ministry of Education, Youth and Sports | 2023-2027 | B. Mrázková | Go to website |
| Metabolic switch in liver regeneration | Czech Science Foundation | 2023-2025 | R. Sedláček | Go to website |
| Novel therapeutic approaches in achondroplasia treatment | Ministry of Health | 2023-2026 | J. Procházka | Go to website |
| Deciphering cellular and molecular principles of choroid plexus development | Czech Science Foundation | 2025-2027 | J. Procházka |
| Grant name | Provider | Duration | Investigator | Web |
|---|---|---|---|---|
| Mouse models for investigation of biological functions of novel Kazal-type protease inhibitors LEKTI-2 and LEKTI-3 | Czech Science Foundation | 2008-2010 | R. Sedláček | Go to website |
| Investigating the pathologic role of metalloproteinases in liver using transgenic mice with conditional expression of transgenes | Czech Academy of Sciences | 2008-2012 | R. Sedláček | Go to website |
| The Impact of a Liver-Specific Deficiency of Growth Factor Sheddase ADAM10 on Liver Development and Pathology | Czech Science Foundation | 2010-2013 | R. Sedláček | Go to website |
| Generation of mouse models for targeting stellate cells and myofibroblasts in the liver | Czech Science Foundation | 2010-2013 | R. Sedláček | Go to website |
| Founding of an expert team for the Centre for Phenogenomics | Ministry of Education, Youth and Sports | 2011-2014 | R. Sedláček | Go to website |
| Function of metalloproteinases in colon epithelium and during development of experimental colitis and colon cancer | Czech Science Foundation | 2011-2014 | R. Sedláček | Go to website |
| Coordinating the cooperation of the ESFRI project Infrafrontier with the International Phenotyping Consortium (IMPC) | Seventh Framework Programme EU | 2011-2014 | R. Sedláček | Go to website |
| Founding the Centre of Transgenic Technologies | Ministry of Education, Youth and Sports | 2012-2015 | R. Sedláček, V. Kořínek, Z. Kozmík | Go to website |
| Czech center INFRAFRONTIER - The European infrastructure for phenotyping and archiving of model mammalian genomes | Ministry of Education, Youth and Sports | 2012-2012 | RS. Sedláček | Go to website |
| Analysis of genes Pin1 and CRMP2A and their impact on axon growth, branching and regeneration in vitro and in vivo | Ministry of Education, Youth and Sports | 2012-2016 | M. Balaštík | Go to website |
| Infrafrontier-CZ/Czech Centre for Phenogenomics as a national centre of „The European infrastructure for phenotyping and archiving of model mammalian genomes“: Integration of the Czech national centre into international network | Ministry of Education, Youth and Sports | 2012-2015 | R. Sedláček | Go to website |
| Structural and functional analysis of interaction between calmodulin and plectin isoform 1a | Ministry of Education, Youth and Sports | 2013-2014 | M. Gregor | Go to website |
| Senescence cells elimination in minimal residual tumour disease therapy | Ministry of Health | 2013-2015 | M. Reiniš | Go to website |
| New technology for correction of mutations in monogenetic diseases by targeted reparation of mutations using specific nucleases | Ministry of Health | 2013-2015 | R. Sedláček | Go to website |
| Development of new methods to analyze enviromental genotoxic stress and mutagenicity of potential pharmaceutical compounds. | Technology Agency of the Czech Republic | 2013-2016 | R. Sedláček | Go to website |
| Founding the expert platform for phenotyping and imaging technologies | Ministry of Education, Youth and Sports | 2013-2015 | R. Sedláček, P. Hozák | Go to website |
| Reactivity of pulmonary arteries in pulmonary hypertension | Czech Science Foundation | 2013-2017 | K. Chalupský | Go to website |
| Role of CRMP2 and Pin1 in the pathogenesis of Alzheimers disease | Seventh Framework Programme EU | 2013-2017 | M. Balaštík | Go to website |
| Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation | Seventh Framework Programme EU | 2013-2016 | R. Sedláček | Go to website |
| Utilization of novel mouse strains for investigation of the NK cell regulatory role in development and therapy of cancer | Czech Science Foundation | 2014-2016 | M. Indrová | Go to website |
| Novel Causative Genes Identification and Functional Study for selected Mendelian Disorders | Ministry of Education, Youth and Sports | 2014-2016 | R. Sedláček | Go to website |
| Regulation of heterochromatic gene silencing | Czech Science Foundation | 2015-2017 | K. Chawengsaksophak | Go to website |
| DNA demethylation in the IFNγ signalling pathway modulates tumour progression and tumour-cell interactions with the immune system | Czech Science Foundation | 2015-2017 | M. Reiniš | Go to website |
| Czech Centre for Phenogenomics | Ministry of Education, Youth and Sports | 2016-2019 | R. Sedláček | Go to website |
| BIOCEV: from Fundamental to Applied Research | Ministry of Education, Youth and Sports | 2016-2020 | R. Sedláček | Go to website |
| OXPHOS addiction as a new hallmark in cancer: Its use for development of novel, efficient cancer therapy | Ministry of Health | 2017-2020 | R. Sedláček | Go to website |
| Role of NME7 in insulin resistance and related metabolic disturbances | Czech Science Foundation | 2017-2019 | L. Šedová | Go to website |
| Role of G-protein signaling in the CX3CR1 chemokine receptor function | Czech Academy of Sciences | 2017-2018 | R. Sedláček | |
| Upgrade of the Czech Centre for Phenogenomics: developing towards translation research | Ministry of Education, Youth and Sports | 2017-2020 | R. Sedláček | Go to website |
| Improving genome editing efficiency | EU Framework Programme for Research and Innovation | 2017-2021 | R. Sedláček | Go to website |
| The role of ATF2 transcription factor in development and homeostasis of colon and its involvement in progression of colorectal carcinoma | Ministry of Education, Youth and Sports | 2019-2021 | J. Procházka | Go to website |
| Deciphering biological role of ZNF644 to edit the activity of G9a/GLP methylation complex | Czech Science Foundation | 2019-2021 | R. Sedláček | Go to website |
| Precision Pathobiology for Disease Models | EU Framework Programme for Research and Innovation | 2019-2021 | R. Sedláček | |
| Perspective application of xenosensor nuclear receptors ligands in therapy of cholestatic liver diseases | Czech Science Foundation | 2022-2024 | K. Chalupský | Go to website |
