Laboratory of Transgenic Models of Diseases

Current Grants

Grant name Provider Duration Investigator Web
Perspective application of xenosensor nuclear receptors ligands in therapy of cholestatic liver diseases Czech Science Foundation 2022-2024 K. Chalupský
Gene engineered killer T cells for the therapy of acute myeloid leukemia Ministry of Health 2022-2025 R. Sedláček Go to website
Mitochondrial function is essential for liver tumour formation and liver regeneration Ministry of Health 2022-2025 J. Procházka Go to website
SARS-Cov-2: understanding the entry, multi-organ spread and immune response in the context of vaccination and re-infection Czech Science Foundation 2022-2025 R. Sedláček
Towards precision medicine and gene therapy Czech Academy of Sciences 2022-2026 R. Sedláček Go to website
GetRadi - Gene Therapy of Rare Diseases Horizon Europe 2022-2026 R. Sedláček

 

Past Grants

Grant name Provider Duration Investigator Web
Mouse models for investigation of biological functions of novel Kazal-type protease inhibitors LEKTI-2 and LEKTI-3 Czech Science Foundation 2008-2010 R. Sedláček Go to website
Investigating the pathologic role of metalloproteinases in liver using transgenic mice with conditional expression of transgenes Czech Academy of Sciences 2008-2012 R. Sedláček Go to website
The Impact of a Liver-Specific Deficiency of Growth Factor Sheddase ADAM10 on Liver Development and Pathology Czech Science Foundation 2010-2013 R. Sedláček Go to website
Generation of mouse models for targeting stellate cells and myofibroblasts in the liver Czech Science Foundation 2010-2013 R. Sedláček Go to website
Founding of an expert team for the Centre for Phenogenomics Ministry of Education, Youth and Sports 2011-2014 R. Sedláček Go to website
Function of metalloproteinases in colon epithelium and during development of experimental colitis and colon cancer Czech Science Foundation 2011-2014 R. Sedláček Go to website
Coordinating the cooperation of the ESFRI project Infrafrontier with the International Phenotyping Consortium (IMPC) Seventh Framework Programme EU 2011-2014 R. Sedláček Go to website
Founding the Centre of Transgenic Technologies Ministry of Education, Youth and Sports 2012-2015 R. Sedláček, V. Kořínek, Z. Kozmík Go to website
Czech center INFRAFRONTIER - The European infrastructure for phenotyping and archiving of model mammalian genomes Ministry of Education, Youth and Sports 2012-2012 RS. Sedláček Go to website
Analysis of genes Pin1 and CRMP2A and their impact on axon growth, branching and regeneration in vitro and in vivo Ministry of Education, Youth and Sports 2012-2016 M. Balaštík Go to website
Infrafrontier-CZ/Czech Centre for Phenogenomics as a national centre of „The European infrastructure for phenotyping and archiving of model mammalian genomes“: Integration of the Czech national centre into international network Ministry of Education, Youth and Sports 2012-2015 R. Sedláček Go to website
Structural and functional analysis of interaction between calmodulin and plectin isoform 1a Ministry of Education, Youth and Sports 2013-2014 M. Gregor Go to website
Senescence cells elimination in minimal residual tumour disease therapy Ministry of Health 2013-2015 M. Reiniš Go to website
New technology for correction of mutations in monogenetic diseases by targeted reparation of mutations using specific nucleases Ministry of Health 2013-2015 R. Sedláček Go to website
Development of new methods to analyze enviromental genotoxic stress and mutagenicity of potential pharmaceutical compounds. Technology Agency of the Czech Republic 2013-2016 R. Sedláček Go to website
Founding the expert platform for phenotyping and imaging technologies Ministry of Education, Youth and Sports 2013-2015 R. Sedláček, P. Hozák Go to website
Reactivity of pulmonary arteries in pulmonary hypertension Czech Science Foundation 2013-2017 K. Chalupský Go to website
Role of CRMP2 and Pin1 in the pathogenesis of Alzheimers disease Seventh Framework Programme EU 2013-2017 M. Balaštík Go to website
Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation Seventh Framework Programme EU 2013-2016 R. Sedláček Go to website
Utilization of novel mouse strains for investigation of the NK cell regulatory role in development and therapy of cancer Czech Science Foundation 2014-2016 M. Indrová Go to website
Novel Causative Genes Identification and Functional Study for selected Mendelian Disorders Ministry of Education, Youth and Sports 2014-2016 R. Sedláček Go to website
Regulation of heterochromatic gene silencing Czech Science Foundation 2015-2017 K. Chawengsaksophak Go to website
DNA demethylation in the IFNγ signalling pathway modulates tumour progression and tumour-cell interactions with the immune system Czech Science Foundation 2015-2017 M. Reiniš Go to website
Czech Centre for Phenogenomics Ministry of Education, Youth and Sports 2016-2019 R. Sedláček Go to website
BIOCEV: from Fundamental to Applied Research Ministry of Education, Youth and Sports 2016-2020 R. Sedláček Go to website
OXPHOS addiction as a new hallmark in cancer: Its use for development of novel, efficient cancer therapy Ministry of Health 2017-2020 R. Sedláček Go to website
Role of NME7 in insulin resistance and related metabolic disturbances Czech Science Foundation 2017-2019 L. Šedová Go to website
Role of G-protein signaling in the CX3CR1 chemokine receptor function Czech Academy of Sciences 2017-2018 R. Sedláček
Upgrade of the Czech Centre for Phenogenomics: developing towards translation research Ministry of Education, Youth and Sports 2017-2020 R. Sedláček Go to website
Improving genome editing efficiency EU Framework Programme for Research and Innovation 2017-2021 R. Sedláček Go to website
The role of ATF2 transcription factor in development and homeostasis of colon and its involvement in progression of colorectal carcinoma Ministry of Education, Youth and Sports 2019-2021 J. Procházka Go to website
Deciphering biological role of ZNF644 to edit the activity of G9a/GLP methylation complex Czech Science Foundation 2019-2021 R. Sedláček Go to website
Precision Pathobiology for Disease Models EU Framework Programme for Research and Innovation 2019-2021 R. Sedláček

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