Laboratory of Leukocyte Signalling


Immunology – Faculty of Science, Charles University

The lecture course “Immunology” (MB150P14B) provides a broad basic overview of modern immunology with emphasis on molecular and cellular principles of functioning of the immune system. The second half of the course dels with the roles of particular immune mechanisms in the defence agains various pathogens, in anti-tumor responses and in various immunopathological reactions (autoimmunity, allergies, immunodeficiencies).


1.Basic terms; functions and components of the immune system
2.Phagocytes and other cellular components of non-specific immunity
3.Complement and other non-adaptive mechanisms
5.Antigen-specific receptors
6.MHC glycoproteins-presentation of peptide fragments
7.Adhesion receptors, Fc-receptors and other surface molecules of leucocytes
9.Signalling receptors used by immunoreceptors
10.Antigen-specific receptors of T- and B-lymphocytes: mechanisms of repertoire generation
11.Immune reactions based on T-lymphocytes and NK-cells
12.Immune reactions based on antibodies
13.Regulation of the immune system
14.Mucosal and skin immune system
15.Anti-infection immunity
16.Anti-tumour immunity
18.Immunopatho-logical reactions
19.Autoimmune diseases
21.Possible therapeutic interventions in the immune system