Institute of Molecular Genetics of the Czech Academy of Sciences
Laboratory of Haematooncology
Open PhD positions
Project: Impact of inflammation on haematopoietic stem and progenitor cells: Unraveling the effects and mechanistic insights
Meritxell Alberich Jordà
Haematopoietic stem and progenitor cells (HSPCs) constitute an essential population of cells which reside in the bone marrow. They orchestrate the continuous generation of mature blood cells throughout an individual’s lifespan, and thus the preservation and maintenance of their function is critical for the process of haematopoiesis. Disruptions in the HSPC pool have been associated with the onset of leukemia, underscoring the significance of understanding and safeguarding their integrity. Our recent publications shed light on the effects that inflammation exerts on HSPCs, leading to changes in their characteristics and function. In this project, we will explore the regulatory mechanism that protect and maintain HSPCs, determine how they are altered under inflammatory conditions, and investigate how to develop strategies to reverse the detrimental effects observed. To achieve these goals, we will employ a multifaceted approach, combining in vitro cell cultures, murine models, and -omics screenings. In essence, this research stands as a pivotal exploration into the dynamic interplay between inflammation and HSPC regulation, with the ultimate aim of contributing to the development of targeted therapeutic strategies for preserving haematopoietic homeostasis and preventing the onset of debilitating conditions such as leukemia.
The laboratory of haematooncology is searching for a highly motivated, enthusiastic and hard-working Ph.D. student. The candidate should hold a master degree in genetics, molecular biology, cell biology, or in a related field. Previous animal work and bioinformatic skills will be positively evaluated. The candidate should be willing to work with murine models. Excellent English is required. The candidate should be a team-player and willing to work with other lab members and international collaborators. We offer a friendly, international, and supporting environment in a state-of-the-art institution.
Burocziova M, Grusanovic S, Vanickova K, Kosanovic S, Alberich-Jorda M: Chronic Inflammation Promotes Cancer Progression as a Second hit. Exp Hematol 2023. [pubmed] [doi]
Vanickova K, Milosevic M, Ribeiro Bas I, Burocziova M, Yokota A, Danek P, Grusanovic S, Chiliński M, Plewczynski D, Rohlena J, Hirai H, Rohlenova K, Alberich-Jorda M: Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis. EMBO J 2023, e113527. [pubmed] [doi]
Grusanovic S, Danek P, Kuzmina M, Adamcova MK, Burocziova M, Mikyskova R, Vanickova K, Kosanovic S, Pokorna J, Reinis M, Brdicka T, Alberich-Jorda M: Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway. EMBO Rep 2022, e54729. [pubmed] [doi]
Danek P, Kardosova M, Janeckova L, Karkoulia E, Vanickova K, Fabisik M, Lozano Asencio C, Benoukraf T, Tirado-Magallanes R, Zhou Q, Burocziova M, Rahmatova S, Pytlik R, Brdicka T, Tenen DG, Korinek V, Alberich Jorda M: β-catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation. Blood 2020. [pubmed] [doi]