PhD Programme

Open PhD positions

Cancer Biology

The main function of the ubiquitin-proteasome system (UPS) is to degrade unneeded or damaged proteins. Cullin-RING ubiquitin ligases (CRLs) mediate ubiquitination of numerous substrates. Our main research focus is to reveal novel substrates of CRLs involved in cancer progression, stress response or cell cycle…

Project: Proteasome control of apoptosis regulation in cancer

Signal Transduction

Our laboratory is focused on understanding the molecular mechanisms governing signal transduction from the plasma membrane receptors to the cytoplasm…

Project: Inhibitory plasma membrane receptor LAIR-1 in mast cell physiology and mastocytosis

Tissue Morphogenesis and Cancer

In our laboratory we study processes and mechanisms, which govern epithelial morphogenesis and homeostasis, and how their deregulation can lead to developmental defects and cancer…

Project: Fibroblast mechanical forces in mammary epithelial morphogenesis

Epigenetic Regulations

The group studies evolution of genes and their regulations, particularly post-transcriptional regulations and genes that mediate it, mainly in the context of the female germline in mice…

Project: Evolution of small RNA silencing pathways in animals

Adaptive Immunity

(Cilia Team)

We uncover mechanisms how cells employ their “antenna” called cilium to sense and respond to extracellular signals within our bodies. The failure of these mechanisms leads to severe diseases manifesting with obesity, neurodegeneration and dysfunction of multiple organs.

Project: Ciliary signaling in neurons and its failure leading to obesity and neurodegeneration