PhD Programme

Open PhD positions

Leukocyte Signalling

Our laboratory is studying the molecular mechanisms of how various leukocyte proteins regulate signal transduction by surface receptors and how their dysfunction triggers disease. Within this relatively broad field, our research focuses mainly on membrane adaptor proteins and Src-family kinases (SFK) and on their roles in inflammation and haematopoiesis…

Project: Signaling pathways in inflammation and autoinflammatory disease

Genome Dynamics

The main research of our group is focused on ADP-ribosyl transferases; a class of DNA repair enzymes that detect DNA single-strand breaks (SSBs) and signal their presence by catalysing the rapid synthesis of mono(ADP-ribose) and poly(ADP-ribose) and hydrolases; enzymes that catalyse the removal of specific ADP-ribosyl modifications from proteins…

Project: Defective DNA damage responses and RNA processing in human disease

Transcriptional Regulation

We investigate embryonic development using an integrative approach combining molecular biology, cell biology, developmental biology, genetics, biochemistry, and bioinformatics in order to get insight into the molecular mechanisms underlying the process of animal development and its tinkering during the course of evolution…

Project: Developmental genetics of amphioxus: a window into the evolution of vertebrate body plan

Cancer Cell Biology

In our laboratory, we employ cell and molecular biology approaches, CRISPR-mediated gene editing and transgenic mouse models to investigate how cells respond to DNA damage. We also seek for genetic defects in cancer cells that could be exploited for personalized cancer treatment…

Project: Function of PPM1D phosphatase in control of genome integrity in human cells
Project: Mechanisms resolving non-canonical DNA structures and their role in genome maintenance

Developmental Mechanobiology

The shape of an animal arises in a species-specific, step-wise fashion during embryonic development. During this sequence of events, collectively referred to as ‘embryo morphogenesis’, the embryo constantly remodels its shape. Our lab is interested in the force-generating mechanisms that drive these shape changes…

Project: A comparative biophysics approach to understand morphogenetic evolution